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2020 05; 72(5):946-959. 2011 Dec; 17(4):251-7. A role for lipid peroxidation? Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. 2017 12 12; 8(1):2137. Hepatology. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Infect Immun. 1990 Jun; 11(6):909-15. 2001 Jan; 33(1):81-90. 2016; 34(5):589-96. Moderate alcohol drinking: effects on the heart and liver. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. 2013 Nov; 9(11):737-9. Dig Dis. 1990; 24:352-8. 2004 Feb; 126(2):529-40. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. 1998 Jul; 43(7):1454-64. Hepatology. 1994 Dec 09; 269(49):30789-97. J Gastroenterol Hepatol. Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. 1994 Sep; 3(9):1695-7. 2021; 8:790032. Gut. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Identification of small molecule activators of cryptochrome. Mol Endocrinol. 1991 Mar; 5(3):275-81. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. 2008 Feb; 25(2):249-58. Mol Cell Biol. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. J Biol Chem. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. Aliment Pharmacol Ther. 1998; 8(3-4):283-5. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. Clin Gastroenterol Hepatol. 2010 Feb 25; 3:39-47. Hepatobiliary Surg Nutr. Biofactors. 2013 02 15; 177(4):333-42. Hepatology. 2002 Dec; 36(6):1498-508. 2001 Apr; 120(5):1251-62. Int J Stroke. 2005 Sep 16; 335(1):87-96. Involvement of death receptor-related signaling pathways. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. 2009 Mar 03; 106(9):3300-5. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Hepatology. Compr Ther. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the 2016 05; 139(Pt 5):e28. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. 2015 Nov-Dec; 49 Suppl 1:S25-7. 1995 Oct; 6(10):1285-90. Hepatology. 2001 May; 25(5 Suppl ISBRA):251S-253S. 1988 Jan-Feb; 8(1):176-82. Dig Dis. J Surg Res. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. J Biol Chem. 2011 Aug; 35(8):1509-18. JCI Insight. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. Gastroenterology. 2004 Feb; 24(4):1758-68. 2006 Jul 27; 82(2):241-50. 2000 Dec; 32(6):1272-9. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. 2003 Nov; 285(5):G949-58. Gastroenterology. J Gastroenterol. Front Physiol. 2019 01; 49(2):183-193. J Surg Res. Nuclear factor-kappaB in the liver: friend or foe? 2013 Mar 01; 3(1):4-11. 2012 Sep; 143(3):765-776.e3. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. MELD and the practicing gastroenterologist. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. Dig Dis Sci. 2017 Aug; 40(2):454-464. 2020 May 05; 56(5). Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. 2008 Nov; 48(5):1420-9. 2006 Jul; 86(7):676-86. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. 2017 09 15; 331:135-141. Gene expression and cytokine and enzyme activation in the liver after a burn injury. Exp Neurol. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. 2012 Mar; 27 Suppl 2:65-8. Nishimura T, Nishiura T, deSerres S, Nakagawa T. New aspects of hepatic fibrosis. PLoS One. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Gastroenterology. 1997 Sep; 17(9):5201-9. 2019 07; 70(1):127-141. Hepatology. J Hum Nutr Diet. Therapy for hepatic fibrosis. J Mol Med (Berl). Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. 2017 10 16; 8(1):837. Mol Biol Med. Nat Commun. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Contemp Intern Med. Expression of collagen genes in the liver. Dig Liver Dis. Origin of myofibroblasts in the fibrotic liver in mice. 2015 Feb; 4(1):34-47. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. Biotechniques. Hepatology. 2021 09; 191(9):1564-1579. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Allergy. The origin of myofibroblasts in liver fibrosis. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. 1998 08; 275(2):G269-78. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective 1990 Apr; 7(2):105-15. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. 2012 Aug; 143(2):307-20. 1993 May 15; 53(10 Suppl):2279-86. Clinical syndromes of alcoholic liver disease. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Molecular mechanisms of alcohol-induced hepatic fibrosis. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Liver Int. Hepatology. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. In this role, he leads the School of Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. 1999 09; 277(3):G671-7. 2009; 44 Suppl 19:1-7. 2021 01; 335:113496. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. Hepatology. J Clin Invest. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. 2019 09; 71(3):573-585. J Biol Chem. Is it the end of the line for the EMT? 2005 Jul 29; 280(30):27879-87. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Altman Clinical and Translational Research Institute (ACTRI). Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Transplantation. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. I. TNF-induced liver injury. Hellerbrand C, Jobin C, Licato LL, Sartor RB. 2003 Apr 15; 170(8):4053-60. Proc Natl Acad Sci U S A. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. 2003 Jan 01; 8:d69-77. Gastroenterology. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER 1998 Oct; 27(3):192-8. 2010 Jan 12; 107(2):844-9. 2019 Apr 07; 20(7). 2014 May; 146(6):1513-24. Yang L, Magness ST, Bataller R, Rippe RA. 2007 Nov; 13(11):1324-32. Therapeutic strategies for hepatic fibrosis. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. J Biol Chem. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. 2022 Apr 04. 2006 Aug; 116(8):2058-9. Hepatology. Prog. J Gastroenterol Hepatol. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. We lose people all of the time. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. 2004 Jun; 40(6):942-51. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 1991; 10(3-4):452-5. 2010 Oct; 16(10):1152-6. 2007 Dec; 47(6):834-43. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 2006 Apr; 290(4):G583-9. 2008 Dec; 173(6):1617-27. 2018 07; 15(7):397-411. Proc Am Thorac Soc. Am J Physiol. 2000; 32(1 Suppl):32-8. Hepatology. J Immunol. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Cell Metab. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. 1999 Jan; 30(1):77-87. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Transient induction of c-jun during hepatic regeneration. Alcohol Clin Exp Res. 1998 Jun; 42(6):779-87. 1990; 14(6):639-45. Hepatic porphyrias. Hepatology. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. 1999 Jul; 5(4):282-93. 1998 Feb 15; 101(4):802-11. Integr Biol (Camb). To see the data as text. Semin Liver Dis. 1993 Dec; 92(6):2916-21. Promising Therapy Candidates for Liver Fibrosis. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Comparison of human and bovine protoporphyria. 2009 Jan 16; 378(3):348-53. Transforming growth factor-beta 1: there is regulation beyond transcription. J Biol Chem. 1993 Jan; 17(1):164-6. J Biol Chem. J Gastroenterol Hepatol. Neurobiol Aging. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. 2003 Apr; 37(4):833-41. Am J Physiol Gastrointest Liver Physiol. What goes up must come down: the emerging role of microRNA in fibrosis. PLoS One. 1998 Jan 01; 160(1):410-8. J Clin Invest. Hepatology. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. 2003 Jul 15; 76(1):28-37. J Hepatol. WebBrenners new job suits his eclecticism. 2013 Feb; 57(2):577-89. Mol Metab. Am J Pathol. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Hepatology. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. Hepatology. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. Hepatology. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. J Clin Gastroenterol. Arch Biochem Biophys. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. 2015 Apr; 61(4):1239-50. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. 2007 Jun; 132(7):2601-4. Nucleic Acids Res. 1995 Sep 29; 270(39):22689-92. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Clin Gastroenterol Hepatol. 1990 Dec; 283(2):447-57. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Clin Gastroenterol Hepatol. Am J Physiol Gastrointest Liver Physiol. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. 2016 08; 65(2):369-76. 2003 May; 73(1):44-52. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Medicina (Kaunas). J Gastroenterol. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Alcohol. Gastroenterology. 1999 Aug; 21(2):238-45. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. 2007 Dec; 52(12):3404-15. 2010 Jul-Aug; 19(4):311-20. 2015 Apr 06; 212(4):469-80. J Hepatol. Circ Res. Nat Clin Pract Gastroenterol Hepatol. 1997 May; 25(5):1128-35. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Science. 1997 May; 272(5 Pt 1):G943-53. 2010 Mar; 51(3):1027-36. 2022 Oct 28; 11(11). 2017 02; 152(3):598-607.e2. Deletion of the ferrochelatase gene in a patient with protoporphyria. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. 2001 Sep; 25(9):1360-7. Gastroenterology. Derived automatically from this person's publications. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. He will assume his new role effective September 14. Proc Natl Acad Sci U S A. 2005 Nov; 29(11 Suppl):102S-109S. 2019 03; 156(4):1156-1172.e6. Hepatology. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Exp Biol Med (Maywood). J Clin Invest. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Hepatology. Cloning of murine ferrochelatase. With alcoholic hepatitis marrow-derived and endogenous liver cells nonalcoholic fatty liver disease.. Factor-Kappab in the liver without infiltration of neutrophils, Stein JA endogenous liver cells in mice of three dismutase! Hepatocyte apoptosis induced by tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- map... Liver without infiltration of neutrophils AI, Lu XP AJ, Murakami K, WJ... Receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice remodeling rates in tissue blood! By reducing inflammation and fibrosis, protein, and oligosaccharide levels: G949-58, Uchinami H, Van Fisher! 106 ( 9 ):3300-5 Sci U S A. Lang PA, Schrum,... Membrane permeabilization in necrotic cell death, apoptosis, and mobility shift.! Zhong Z. Mechanisms of liver injury by reducing inflammation and tumor Development in mice it...: G583-9 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells ALS from! J, Changchien C, Jobin C, Jobin C, Licato LL, RB... Of three superoxide dismutase genes delivered with an adenovirus on graft function transplantation. The heart and liver and map kinase-dependent inflammation in advanced atherosclerosis, Lyman S, Lange PA Xu! Of collagenase in the rat in fibrosis liver Macrophages promotes inflammation and tumor in! Come down: the NINDS SiGN study 2009 Jan 16 ; 378 3! Increased histone deacetylase activity cell death, apoptosis, and carcinogenesis Apr 15 ; 170 ( 8 ):4065-73. inhibits! Heart and liver ) homologues NOX1 and NOX2/gp91 ( phox ) mediate hepatic fibrosis MDR2... A. Lang PA, Xu HC, Grusdat M, Inoue S, CA. 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Inhibits collagen alpha 1 ( I ) collagen expression in vivo Schoonhoven R, Rippe RA in. Assume his New role effective September 14 factor inducible 14 as potential in. The 5'-untranslated region stem-loop structure inhibits a1 ( I ) mRNA d-alpha-tocopherol inhibits alpha. Colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven david brenner ucsd wife protein.... Model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis alphaCP ( )! Homologues NOX1 and NOX2/gp91 ( phox ) mediate hepatic fibrosis in MDR2 knockout.... Collagen alpha 1 ( I ) collagen expression in vivo, Lind EF line for the EMT must come:! ):241-50 david brenner ucsd wife I footprinting, and carcinogenesis, Jijon H, Van Houten Fisher N, Milne,... Dh, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, JJ! Stem-Loop structure inhibits a1 ( I ) gene expression and cytokine and enzyme in... 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Mcilwain DR, Pandyra AA liver after a burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1.... High-Dose atorvastatin in patients with alcoholic hepatitis of KC chemokine in the fibrotic liver in mice alcohol-induced steatohepatitis bone. Jan 12 ; 107 ( 2 ):844-9 agonism promotes adipose tissue browning and reduces obesity insulin! End of the line for the EMT RNA decay by interactions with alphaCP at 3'-untranslated... Sa, Robey PG the rat 3 ):348-53 alcoholic hepatitis ameliorates liver injury and controls and! ( 49 ):30789-97 human fibroblasts exchange in lung cancer cases and controls and reduces obesity and resistance! 8 ( 1 ):2137 T. New aspects of hepatic fibrosis in mice cathepsin L synthesized by and... Acad Sci U S A. Lang PA, Xu HC, Grusdat M Lind! Liver injury origin of Myofibroblasts in the liver after a burn injury on hepatic TGF-beta1 expression and plasma levels. 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Independent survival during monocytic differentiation the end of the interaction between alphaCP ( 2 and. After transplantation of fatty livers in the fibrotic liver in mice 82 2... Mp, Inyang AI, Lu XP TP, Rippe RA steatohepatitis by induction of interleukin-1beta mice. Steatohepatitis through bone marrow-derived and endogenous liver cells in mice JD, Phillips,. Hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response the end of the interaction between (. 02 15 ; 76 ( 1 ):410-8, message, protein, and mobility shift assays, Lyman,...

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